Publications

Chemotherapy induces canalisation of cell state in childhood B-cell precursor acute lymphoblastic leukemia

VA Turati, JA Guerra-Assunção, NE Potter, R Gupta, S Ecker, A Daneviciute, M Tarabichi, AP Webster, C Ding, G May, C James, J Brown, L Conde, LJ Russell, P Ancliff, S Inglott, G Cazzaniga, A Biondi, GW Hall, M Lynch, M Hubank, I Macaulay, S Beck, P Van Loo, SE Jacobsen, M Greaves, J Herrero, T Enver (Nature Cancer July 2021)

Link: https://doi.org/10.1038/s43018-021-00219-3


The Evolving molecular landscape of intestinal and pulmonary neuroendocrine tumours

AP Webster, C Thirlwell (Current Opinion in Endocrine and Metabolic Research May 2021)

Link: https://doi.org/10.1016/j.coemr.2021.05.004


GenomeChronicler: The Personal Genome Project UK Genomic Report Generator Pipeline

JA Guerra-Assunção, L Conde, I Moghul, AP WebsterS Ecker, O Chervova, C Chatzipantsiou, PP Prieto, S Beck, J Herrero (Frontiers in Genetics September 2020)

Link: https://doi.org/10.3389/fgene.2020.518644


Epigenome-wide methylation profile of chronic kidney disease-derived arterial DNA uncovers novel pathways in disease-associated cardiovascular pathology

A Dritsoula, M Kislikova, A Oomatia, AP WebsterS Beck, M Ponticos, B Lindsey, J Norman, DC Wheeler, T Oates, B Caplin (Epigenetics September 2020)

Link: https://doi.org/10.1080/15592294.2020.1819666


The Personal Genome Project UK: an open access resource of human multi-omics data

O Chervova, L Conde, JA Guerra-Assuncao, I Moghul, AP Webster, A Berner, EL Cadieux, Y Tian, V Voloshin, TF Jesus, R Hamoudi, J Herrero, S Beck (Scientific Data, October 2019)

Link: https://www.nature.com/articles/s41597-019-0205-4


Diagnostic Approaches to Neuroendocrine Neoplasms of Unknown Primary Site

A Berner, C Pipinikas, A Ryan, H Dibra, I Moghul, AP Webster, TV Luong, C Thirlwell (Neuroendocrinology, October 2019)


A CellAge epigenetic clock for expedited discovery of anti-ageing compounds in vitro

C Lujan, EJ Tyler, AP Webster, ER Stead, VE Martinez Miguel, S Ecker, D Milligan, JC Garbe, MR Stampfer, S Beck, R Lowe, CL Bishop, I Bjedov (bioRxiv, October 2019)

Link: https://doi.org/10.1101/803676


Points-to-consider on the return of results in epigenetic research

SOM Dyke, KM Saulnier, C Dupras, AP Webster, K Maschke, M Rothstein, R Siebert, J Walter, S Beck, T Pastinen, Y Joly (Genome Medicine, May 2019)

Link: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-019-0646-6


Undifferentiated sarcomas develop through distinct tumour evolutionary pathways

CD Steele, M Tarabichi, D Oukrif, AP Webster, H Ye, M Fittall, P Lombard, I Martincorena, PS Tarpey, G Collord, SJ Strauss, F Berisha, H Vaikkinen, P Dhami,  M Jansen, S Behjati, MF Amary, R Tirabosco, A Feber, PJ Campbell, LB Alexandrov, P Van Loo, AM Flanagan, N Pillay (Cancer Cell, March 2019)

Link: https://doi.org/10.1016/j.ccell.2019.02.002


Personal Genome Project UK (PGP-UK): a research and citizen science hybrid project in support of personalized medicine

S Beck, AM Berner, G Bigness, M Bond, MJ Callanan, O Chervova, L Conde, M Corpas, S Ecker, HR Elliott, SA Fioramonti, AM Flanagan, R Gaentzsch, D Graham, JA Guerra-Assuncao, R Hamoudi, V Harding, PL Harrison, J Herrero, J Hofmann, E Jones, S Khan, J Kaye, P Kerr, E Libertini, L McCormack, I Moghul, N Pontikos, S Rajanayagam, K Rana, M Semega-Janneh, CP Smith, L Strom, S Umur,  AP Webster, EH Williams, K Wint, JN Wood (BMC Medical Genomics, November 2018)

Link: https://doi.org/10.1186/s12920-018-0423-1


Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

AP Webster, D Plant, S Ecker, F Zufferey, JT Bell, A Feber, DS Paul, S Beck, A Barton, FMK Williams, J Worthington (Genome Medicine, September 2018)

Link: https://doi.org/10.1186/s13073-018-0575-9


A novel cell-type deconvolution algorithm reveals substantial contamination by immune cells in saliva, buccal and cervix

SC Zheng, AP Webster, D Dong, A Feber, DG Graham, R Sullivan, S Jevons, LB Lovat, S Beck, M Widschwendter, AE Teschendorff (Epigenomics, April 2018)

Link: https://www.futuremedicine.com/doi/pdf/10.2217/epi-2018-0037


ChAMP: Updated Methylation Analysis Pipeline for Illumina BeadChips

Y Tian, T Morris, AP Webster, Z Yang, S Beck, A Feber, AE Teschendorff (Bioinformatics, August 2017)

Link: https://doi.org/10.1093/bioinformatics/btx513


Differential methylation as a biomarker of response to etanercept in patients with rheumatoid arthritis

D Plant*, AP Webster*, N Nair, J Oliver, S Smith, S Eyre, K Hyrich, A Wilson, A Morgan, J Isaacs, J Worthington, A Barton (Arthritis & Rheumatology, January 2016) *these authors contributed equally to the work

Link: http://onlinelibrary.wiley.com/doi/10.1002/art.39590/abstract


Cryopreservation of cells does not substantially alter the DNA methylome of CD3+CD4+ T cells

AP Webster, S Smith, J Worthington, A Barton, D Plant (Scandinavian Journal of Rheumatology, December 2015)

Link: https://doi.org/10.3109/03009742.2015.1115896 


A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation

D Paul, A Jones, R Sellar, N Mayor, A Feber, AP Webster, N Afonso, R Sergeant, R Szydlo, J Apperley, M Widschwendter, S Mackinnon, S Marsh, J Madrigal, V Rakyan, K Peggs,S Beck (Genome Medicine, December 2015)

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681168/


Genetic and genomic markers of anti-TNF treatment response in rheumatoid arthritis

J Oliver, D Plant, AP Webster, A Barton (Biomarkers in Medicine, June 2015)

Link: http://www.futuremedicine.com/doi/pdf/10.2217/bmm.15.18